Overview
Top Medical Research Studies
Both PS and atorvastatin-loaded PS liposomes effectively lowered LDL and total cholesterol without impacting other lipid levels. While we observed significant improvements in plaque characteristics and intima-media thickness, other factors like triglycerides and HDL remained unchanged.
Overall, PS liposomes appear promising for improving lipid profiles and aiding in plaque regression.
Results showed that PhyS-milk significantly reduced LDL cholesterol levels more than ω3-milk and improved LDL's resistance to oxidation. While ω3-milk impacted triglycerides, PhyS-milk primarily altered LDL lipid composition.
Overall, both milk variants contributed to healthier LDL profiles, suggesting benefits beyond just lowering cholesterol and triglycerides.
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Both PS and atorvastatin-loaded PS liposomes effectively lowered LDL and total cholesterol without impacting other lipid levels. While we observed significant improvements in plaque characteristics and intima-media thickness, other factors like triglycerides and HDL remained unchanged.
Overall, PS liposomes appear promising for improving lipid profiles and aiding in plaque regression.
Results showed that PhyS-milk significantly reduced LDL cholesterol levels more than ω3-milk and improved LDL's resistance to oxidation. While ω3-milk impacted triglycerides, PhyS-milk primarily altered LDL lipid composition.
Overall, both milk variants contributed to healthier LDL profiles, suggesting benefits beyond just lowering cholesterol and triglycerides.
This indicates that atorvastatin may not only help manage cholesterol but also normalize platelet function, offering broader cardiovascular benefits.
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Frequently Asked Questions
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Phosphatidylserine is a phospholipid that is a vital component of cell membranes, particularly within the brain. It plays a crucial role in cellular function, including cell signaling, apoptosis (programmed cell death), and maintaining the structure of neuronal membranes. As a dietary supplement, phosphatidylserine is often marketed for its potential cognitive benefits, including improving memory, attention, and overall mental clarity, particularly in aging populations. While some studies have suggested that it may help reduce symptoms of cognitive decline and stress, more research is needed to fully understand its effectiveness and the mechanisms behind its action.
Phosphatidylserine can be obtained from dietary sources, such as soybeans, white beans, and egg yolks, though supplementation is common for those looking for higher doses. When considering a phosphatidylserine supplement, it's important to look for high-quality, reputable brands and consult with a healthcare professional, especially if you’re pregnant, nursing, or taking other medications. The safety profile of phosphatidylserine is generally good, although some may experience gastrointestinal discomfort as a side effect.
Based on user reviews, it appears that individuals often begin to see improvements in their cholesterol levels after about two months of consistent use of the supplement. For instance, one user noted that after taking the supplement for two months, their cholesterol levels had improved significantly, reflecting a better lipid profile (Read Review). Another review echoed this timeline, mentioning successful management of cholesterol levels after two months of supplementation combined with a proper diet (Read Review).
Various other users reported positive outcomes in cholesterol management, indicating that a consistent intake of the supplement aids in normalizing cholesterol levels within a similar timeframe. For example, one user highlighted that with regular usage, their cholesterol levels had decreased markedly (Read Review), while another noted that the product effectively lowered their cholesterol levels (Read Review). Overall, if you're considering this supplement, be prepared to commit to consistent intake for at least two months to gauge its effect on your cholesterol levels.
The use of phosphatidylserine (PS) liposomes appears promising for managing high cholesterol, based on research findings. In a study involving rabbits on a high-fat diet, PS liposomes significantly reduced harmful LDL cholesterol and plaque size, indicating potential for improved lipid profiles and atherosclerosis management [1]. Further research with ApoE-/- mice demonstrated a notable 53% decrease in atherosclerotic lesions when PSLs were part of a high-fat diet regimen, suggesting an immune-enhancing effect could contribute to lowered inflammation and cholesterol levels [3]. These results highlight PS liposomes as a potential therapeutic option, although further studies in humans are necessary to establish their efficacy.
Additionally, phytosterol (PhyS) enriched milk has been shown to effectively reduce LDL cholesterol levels more than omega-3 enriched milk in overweight individuals, indicating its role in promoting healthier cholesterol profiles [2]. This research underscores the importance of functional food products in cholesterol management. Overall, while these supplements show promise, it's crucial for consumers to seek further research and clinical evidence to solidify their role in effectively managing high cholesterol.
Users have reported a range of positive improvements in symptoms related to cholesterol management and overall wellness after using the supplement. Many individuals noted significant reductions in their cholesterol levels alongside enhanced lipid profiles. For instance, one user shared that after two months of consistent use, their cholesterol levels improved markedly and their lipid profile was significantly better (Read Review). Another user echoed similar sentiments, indicating that regular intake effectively normalizes cholesterol levels, highlighting an essential benefit for overall heart health (Read Review).
In addition to cholesterol regulation, several users reported ancillary benefits such as improved fat metabolism. One user mentioned that they experienced a drop in cholesterol after following a specific regimen of supplementation (Read Review). Overall, users have indicated that with consistent usage, they are seeing tangible results. However, results can vary individually, and it’s essential to combine supplementation with a proper diet and lifestyle for optimal outcomes.
Users have reported encouraging results when combining this supplement with other dietary aids to manage high cholesterol. Many individuals highlighted that alongside the supplement, dietary changes and additional supplements, like lecithin, played a pivotal role in normalizing cholesterol levels. For instance, a user noted that after two months of taking lecithin prescribed by their doctor, their cholesterol was returning to normal, thanks to both the supplement and proper dietary adherence (Read Review). Similarly, other users pointed out that consistent usage of phosphatidylserine led not only to improved cholesterol levels but also supported fat metabolism when paired with meals (Read Review).
Additionally, some users emphasized the effectiveness of the supplement in conjunction with a robust regimen. For example, a review highlighted significant cholesterol reduction when taken with meals, indicating a clear synergy between the supplement and dietary considerations (Read Review). Overall, the insights from user reviews suggest that optimal results in managing cholesterol levels can often be achieved through a combination of consistent supplementation, dietary adjustments, and possibly other supporting supplements.
Based on user reviews, there is a consensus on the effectiveness of Phosphatidylserine in helping to normalize or lower cholesterol levels. Many users reported significant improvements in their lipid profiles after consistent use. For instance, one review highlighted that after taking the supplement for two months, their cholesterol levels saw a notable improvement ((Read Review)). Another user mentioned taking one capsule three times a day with meals, which contributed to a decrease in cholesterol levels ((Read Review)).
While specific dosage information is somewhat sparse, users suggest a range from taking one capsule three times a day, to higher dosages such as 4-5 tablets before bedtime for additional health benefits ((Read Review)). Overall, those who took Phosphatidylserine consistently reported positive results, underscoring the importance of regular use in managing high cholesterol effectively.
Both PS and atorvastatin-loaded PS liposomes effectively lowered LDL and total cholesterol without impacting other lipid levels. While we observed significant improvements in plaque characteristics and intima-media thickness, other factors like triglycerides and HDL remained unchanged.
Overall, PS liposomes appear promising for improving lipid profiles and aiding in plaque regression.
Results showed that PhyS-milk significantly reduced LDL cholesterol levels more than ω3-milk and improved LDL's resistance to oxidation. While ω3-milk impacted triglycerides, PhyS-milk primarily altered LDL lipid composition.
Overall, both milk variants contributed to healthier LDL profiles, suggesting benefits beyond just lowering cholesterol and triglycerides.
References
- Naeini MB, Momtazi-Borojeni AA, Ganjali S, Kontush A, Jaafari MR, et al. Phosphatidylserine-containing liposomes: Therapeutic potentials against hypercholesterolemia and atherosclerosis. Eur J Pharmacol. 2021;908:174308. doi:10.1016/j.ejphar.2021.174308
- Padro T, Vilahur G, Sánchez-Hernández J, Hernández M, Antonijoan RM, et al. Lipidomic changes of LDL in overweight and moderately hypercholesterolemic subjects taking phytosterol- and omega-3-supplemented milk. J Lipid Res. 2015;56:1043. doi:10.1194/jlr.P052217
- Hosseini H, Li Y, Kanellakis P, Tay C, Cao A, et al. Phosphatidylserine liposomes mimic apoptotic cells to attenuate atherosclerosis by expanding polyreactive IgM producing B1a lymphocytes. Cardiovasc Res. 2015;106:443. doi:10.1093/cvr/cvv037
- Labiós M, Martínez M, Gabriel F, Guiral V, Martínez E, et al. Effect of atorvastatin upon platelet activation in hypercholesterolemia, evaluated by flow cytometry. Thromb Res. 2005;115:263.
